Customized Hormone Replacement Therapy

Today’s women prefer natural hormones. In a national survey of 1,009 women aged 40 and older, 83% said they would prefer to use hormones that are similar to their own body’s hormones.

Goals of Customized, Natural HRT

Alleviate the symptoms caused by the natural decrease in production of hormones by the body

Give the protective benefits which were originally provided by naturally occurring hormones

Re-establish a hormonal balance

The three types of hormones typically prescribed for customized hormone replacement therapy are estrogens, progesterone, and androgens. The precise components of each woman’s therapy need to be determined after physical examination, medical history, and laboratory testing are considered. Close monitoring is essential to ensure that appropriate dosage adjustments are made.

Estrogens:

are often prescribed in combination to re-establish a normal physiologic balance

relieve menopausal symptoms, including vaginal thinning and dryness

may increase HDL “good” cholesterol and decrease LDL “bad” cholesterol

help to decrease blood pressure and reduce plaque formation on the arterial walls

reduce the risk of colorectal cancer

may improve mood, energy levels, and sleep patterns

may reduce the risk of developing or the severity of type 2 diabetes

may improve memory and cognitive function

reduce bone loss

Progesterone:

is commonly prescribed for perimenopausal women to counteract “estrogen dominance”

alone, or with estrogen, may improve Bone Mineral Density

minimizes the risk of endometrial cancer in women who are receiving estrogen

is preferred by women who had previously taken synthetic forms of progesterone known as progestins, according to one Mayo Clinic study

may enhance the beneficial effect of estrogen on lipid and cholesterol profiles in post-menopausal women (in contrast to synthetic medroxyprogesterone acetate)

Androgens, such as testosterone, are prescribed for women to:

enhance libido

provide cardiovascular protection (lower cholesterol)

enhance bone building (increase calcium retention)

improve energy levels and mental alertness

Recently, attention has turned to the addition of the androgens testosterone and dehydroepiandrosterone (DHEA) to estrogen replacement therapy to alleviate recalcitrant menopausal symptoms and further protect against osteoporosis, loss of immune function, obesity, and diabetes.

Every woman is unique. Therefore, it is a sensible approach for the patient to work together with health care professionals to customize hormone replacement therapy. HRT can be customized in the needed strength and dosage form and administered via the most appropriate route to meet each woman’s individual needs.

January 2016

Natural Progesterone Can Slow Breast Cancer

A large team of scientists have determined that natural progesterone has the potential to slow the growth of many breast cancer tumors or even shrink them, unlike synthetic progestins which increase breast cancer risks.

It has long been known that tumors with estrogen receptors (ER) and progesterone receptors (PR) – termed ER/PR double positive – have the best clinical outcome. A study conducted by researchers from prestigious institutions including the Cancer Research UK Cambridge Institute; University of Adelaide, Australia; University of Texas, Southwestern Medical Center at Dallas; and University of North Carolina at Chapel Hill explain why double positive breast cancer patients have the best chance of survival. The finding could benefit up to half of all breast cancer patients.

Scientists know that when activated by most forms of estrogen – especially estradiol and its metabolites – estrogen receptors turn on genes within cancerous cells that program those cells to multiply rapidly and stay alive rather than die off as normal, healthy cells do. When activated by progesterone, progesterone receptors attach themselves to estrogen receptors. Once this happens, estrogen receptors stop turning on genes that promote the growth of the cancer cells. Instead, they turn on genes that promote the death of cancer cells (apoptosis) and stimulate the growth of healthy, normal cells.

The researchers pointed out that only natural, bio-identical progesterone slows the growth of breast cancer. Conversely, synthetic progestins (molecularly altered forms of progesterone including medroxyprogesterone acetate and other progesterone derivatives found in birth control pills) have been shown to increase rather than decrease breast cancer risks.

This is exciting news for women who are diagnosed with ER/PR positive breast cancers. If such women have healthy progesterone levels, or when progesterone levels are increased through natural progesterone supplementation, treatment outcomes may improve significantly.

Hormonal imbalances have reached epidemic proportions in most developed countries over the last several decades. Due to poor diets, lack of exercise, a rise in obesity levels, the widespread use of hormone-altering chemicals, and other factors, many women suffer from chronically higher than normal estrogen levels and much lower than normal progesterone levels.

In their book What Your Doctor May Not Tell You About Breast Cancer, John R. Lee, M.D. and David Zava, Ph.D. noted that women with progesterone levels that are low relative to estrogen levels are more likely to get breast cancer and have poorer treatment outcomes. They concluded that estrogen dominance causes estrogen receptors to activate genes such as BCL-2 that are known to promote the rapid growth of cancer cells. They theorized that chronic states of estrogen dominance contribute to high rates of breast cancer, and their theory has been validated with this latest research.

Ask our compounding pharmacist for more information about the benefits of balancing hormones using natural progesterone. We will work together with you and your health care provider to customize medications in the proper dosage to meet your unique needs.

References
Nature 2015; 523; 313-317.
Pharmaceutical Journal, 17 Jul 2015.
John R. Lee, M.D.; David Zava, Ph.D.; and Virginia Hopkins. “What Your Doctor May Not Tell You About Breast Cancer.” 2002
www.johnleemd.com/natural-progesterone-treat-breast-cancer.html

January 13, 2016 By JJRX 2016 breast cancer, health, women health, women's health

February 2016

Customized Hormone Replacement Therapy

January 2016

Natural Progesterone Can Slow Breast Cancer

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